Subjects: Biology >> Biochemistry submitted time 2020-02-12
Abstract: A recent outbreak of pneumonia in Wuhan, China was caused by 2019 novel coronavirus (2019-nCoV). Here we reported 12 patients with 2019-nCoV infections in Shenzhen, China; all of them developed pneumonia and half developed acute respiratory distress syndrome (ARDS). We demonstrated the plasma cytokine profiles of these 12 patients. Thirty-eight out of 48 cytokines measured in the plasmas of 2019-nCoV infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV load. Fifteen cytokines, M-CSF, IL-10, IFN-2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-γ, IL-1, IL-2, HGF, and PDGF-BB, were strongly associated with lung injury Murray score, and could predict disease severity of 2019-nCoV infections according to area under the curve (AUC) of the receiver-operating characteristics (ROC) calculations. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of these cytokines could be potential biomarkers of disease severity of 2019-nCoV infections. These findings improve our understanding of the immunopathologic mechanisms of this emerging and still evolving disease and suggest that modulators of cytokine responses could play a therapeutic role in combating the disease. " "
Peer Review Status:Awaiting Review